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How to restore aged skin with a collagen biostimulator

The face of a woman with a youthful appearance

Collagen loss is a major contributor to facial aging. Collagen is a fibrous protein that gives structure and support to the skin. When the skin’s collagen content decreases with age, it gives rise to typical signs of ageing such as saggy and loose skin and wrinkles. 

The purpose of collagen biostimulators is to activate collagen renewal in the skin, and thereby help restore its inner structure and volume. Does it really work and exactly how do collagen biostimulators help restore the skin? Find out in the article.

What is a collagen biostimulator?

A collagen biostimulator consists of a substance that is injected into the deep dermis, the middle layer of the skin. Once injected, the substance will stimulate collagen production. A treatment with a collagen biostimulator is a so-called minimally invasive treatment, with little or no downtime. The effect is gradual; results are generally visible a few months after the initial treatment and last up to two years or even longer.1

The first collagen biostimulator that was launched uses poly-L-lactic acid (PLLA) to revitalize collagen production. PLLA is a substance that is otherwise used in dissolvable stitches for wound management.2-3 Since the launch of the original biostimulator with PLLA, another biostimulator has been launched that uses calcium hydroxylapatite, a mineral that is found in human bones and teeth. This article will primarily cover the PLLA biostimulator, however, the mechanism of action is similar.

How does it work?

For the product that uses PLLA microparticles, the microparticles are first reconstituted in sterile water and are then injected into the deep dermis. Immediately after the treatment, water and other constituents in the product will cause a temporal swelling and thereby reduce the appearance of wrinkles and loose skin. Within a few days, the body will absorb the liquid and the defects will appear uncorrected again. 

Gradually, the collagen stimulator will replace the structural support lost during ageing and improve skin laxity.4

Gradual and long-lasting results

A collagen biostimulator is not a quick-fix. When it comes to the PLLA biostimulator, the effects appear gradually over the course of several months and can last for up to two years or more.1

Gradual and long-lasting effects are also what most consumers are looking for. In a clinical study, 75 percent of the women preferred gradual results that last two years over immediate results lasting 12 months.5 Another study has shown that women over 50 are dissatisfied with physical changes like sagging skin and feel trapped within an older body.This is where a collagen biostimulator can make a difference as it targets collagen loss — one of the major contributors to loose skin and wrinkles.

What results can you expect?

According to clinical studies, a PLLA biostimulator activates the body’s ability to produce collagen, which restores the skin’s inner structure and renews its natural firmness.4,7,8

It is important to know that it is difficult to get an exact measure of firmness and elasticity. Often, indirect measurement methods are used, for example, a cutometer. A cutometer uses a small probe that is pressed to the skin surface. The skin is then exposed to a negative pressure, which will draw the skin into the probe (also called suction method). The resistance of the skin to the negative pressure is interpreted as skin firmness and its ability to return to its original position (when the negative pressure has been discontinued) is interpreted as skin elasticity.

It is often easier and more straightforward to take a before and after photo to evaluate changes in loose skin, deep folds, wrinkles and other signs of ageing that you wish to reduce. This is a wise recommendation for all kinds of aesthetic treatments. 

The images below show the result of a PLLA biostimulator before and 25 months after treatment.                                                  

What results can you expect

Just like other aesthetic treatments, biostimulators can cause side effects, even if it is a minimally invasive procedure. To better understand the benefits as well as side effects, you should always consult with an experienced healthcare practitioner.

Learn more about collagen here.


  1. Narins RS, Baumann L, Brandt FS, et al. A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles. J Am Acad Dermatol. 2010 Mar; 62(3):448-62.

  2. McKeen LW. Plastics used in medical devices. In: Modjarrad K, Ebnesajjad S,eds. Handbook of Polymer Applications in Medicine and Medical Devices. Oxford, England; Elsevier; 2014; 21-52.

  3. Lasprilla AJ, Martinez GA, Lunelli BH, et al. Poly-lactic acid synthesis for application in biomedical devices - a review. Biotechnol Adv. 2012 Jan-Feb; 30(1):321-8.

  4. Stein P, Vitavska O, Kind P, Hoppe W, Wieczorek H, Schürer NY. The biological basis for poly-L-lactic acid-induced augmentation. J Dermatol Sci. 2015 Apr; 78(1):26-33. 

  5. Weinkle S, Lupo M. Attitudes, awareness, and usage of medical antiaging treatments: results of a patient survey. J Clin Aesthet Dermatol. 2010 Sep; 3(9):30-3.

  6. Hofmeier SM, Runfola CD, Sala M, et al. Body image, aging, and identity in women over 50: The Gender and Body Image (GABI) study. J Women Aging. 2017 Jan-Feb; 29(1):3-14.

  7. Vleggaar D, Fitzgerald R, Lorenc ZP. Composition and mechanism of action of poly-L-lactic acid in soft tissue augmentation. J Drugs Dermatol. 2014 Apr; 13(4 Suppl):s29-31.

  8. Goldberg D, Guana A, Volk A, et al. Single-Arm Study for The Characterization of Human Tissue Response To Injectable Polu-L-Lactic Acid. Dermatol Surg. 2013; 39(6): 915-922.